Abstract
Coronary artery bypass surgery (CABG) is still one of the most frequently performed surgical procedures all over the world. The results of this procedure have been constantly improved over the years with low perioperative mortality rates, with relatively low complication rates. To further improve these outstanding results, the clinicians focused their attention at biomarkers as outcome predictors. Although biological testing for disease prediction has already been discussed many times, the role of biomarkers in outcome prediction after CABG is still controversial. In this article, we reviewed the current knowledge regarding the role of genetic and dynamic biomarkers and their possible association with the occurrence of adverse clinical outcomes after CABG. We also took into consideration that the molecular pathway activation and the possible imbalance may affect hard outcomes and graft patency. We analyzed biomarkers classified in two different categories depending on their possibility to change over time: genetic markers and dynamic markers. Moreover, we evaluated these markers by dividing them, into sub-categories, such as inflammation, hemostasis, renin–angiotensin, endothelial function, and other pathways. We showed that biomarkers might be associated with unfavorable outcomes after surgery, and in some cases improved outcome prediction. However, the identification of a specific panel of biomarkers or of some algorithms including biomarkers is still in an early developmental phase. Finally, larger studies are needed to analyze broad panel of biomarkers with the specific aim to evaluate the prediction of hard outcomes and graft patency.
Highlights
According to the European guidelines, coronary artery bypass surgery (CABG), which was introduced in the late sixties, associated with percutaneous intervention (PCI) is still one of the most frequently performed surgical procedures
Coronary artery bypass surgery (CABG) Biomarkers in Outcome Prediction the lesion is not treatable by PCI, CABG remains the treatment of choice in the case of left main trunk disease, reduced cardiac function or severe coronary disease [1, 2], and in the case of diabetes [3, 4] and in the majority of patients affected by three-vessel disease [5, 6]
This study showed that single nucleotide polymorphisms (SNPs) associated with inflammatory molecules [CRP, IL-1α, IL-1β, IL-6, IL-8, IL-10, interleukin 1 receptor antagonist (IL-1RN), and TNFα] did not affect long-term survival after CABG
Summary
According to the European guidelines, coronary artery bypass surgery (CABG), which was introduced in the late sixties, associated with percutaneous intervention (PCI) is still one of the most frequently performed surgical procedures. We reviewed the current knowledge on molecular mechanisms and the association of biomarkers in the occurrence of adverse clinical outcomes after CABG, with a special emphasis on pathway activation and imbalance that may affect hard outcomes and graft patency.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
