Abstract
Background: We have previously shown that oligomeric alpha synuclein is significantly elevated in both basal tears (anesthetized Schirmer's test) and reflex tears (unanesthetized Schirmer's test) in PD patients versus HC. Our patient sample was homogeneous related to disease duration. We have designed this study to evaluate the efficacy of collecting reflex tears to provide a true biomarker capable of differentiating PD progression compared to HC.
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