Abstract
At the onset of cancer, specific biomarkers get elevated or modified in body fluids or tissues. Early diagnosis of these biomarkers can greatly improve the survival rate or facilitate effective treatment with different modalities. Potential nanomaterial-based biosensing and bioimaging are the main techniques in nanodiagnostics because of their ultra-high selectivity and sensitivity. Emerging graphene, including two dimensional (2D) graphene films, three dimensional (3D) graphene architectures and graphene hybrids (GHs) nanostructures, are attracting increasing interests in the field of biosensing and bioimaging. Due to their remarkable optical, electronic, and thermal properties; chemical and mechanical stability; large surface area; and good biocompatibility, graphene-based nanomaterials are applicable alternatives as versatile platforms to detect biomarkers at the early stage of cancer. Moreover, currently, extensive applications of graphene-based biosensing and bioimaging has resulted in promising prospects in cancer diagnosis. We also hope this review will provide critical insights to inspire more exciting researches to address the current remaining problems in this field.
Highlights
Cancer, the second leading cause of death globally, accounts for 8.8 million deaths and possibly over 21 million by 2030 [1]
In the past few years, nanodiagnostics including nanomaterial-based biosensing and bioimaging have attracted enormous interest throughout the scientific community because they brought about unparalleled advances in cancer discovery [2]
We chose to survey graphene-based biosensing and bioimaging approaches concerning cancer biomarkers recognition in the past few years that could serve as alternative means for early cancer diagnosis
Summary
The second leading cause of death globally, accounts for 8.8 million deaths and possibly over 21 million by 2030 [1]. The detection of various cancer biomarkers with biosensing has already been summarized by several reviews [12,13,14,15,16]; specific recognition of biomarkers with bioimaging has been published in some reviews [17,18,19,20] These reviews are related to different diseases, and do not emphasize cancer diagnosis taking advantage of graphene. We chose to survey graphene-based biosensing and bioimaging approaches concerning cancer biomarkers recognition in the past few years that could serve as alternative means for early cancer diagnosis. We chose this topic because the past researches clearly demonstrated that the discovery of graphene has put forward more possibilities in cancer diagnostics and therapies, which is guiding modern medicine. This review is devoted to presenting the recent advancements and future prospects of biomarker-based cancer diagnosis using graphene-based biosensing and bioimaging
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
