Abstract
Biomarkers and neurobiology of schizophrenia
Highlights
Dedicated to the neurobiology of schizophrenia, this issue opens with an immunohistochemical study on changes in hypothalamic VGF expression by Busse et al [1]
The authors claim a better characterization of psychopathological profiles with respect to different schizophrenia phases in longitudinal investigations plus implementing different approaches of proteomics and rigorously adhering to standard procedures according to international CSF guidelines to improve the quality of CSF studies in schizophrenia
While in an unstimulated condition intracellular monocytic IL-6 levels at baseline were significantly lower in schizophrenic patients than controls, after mimicking an infection via stimulation with lipopolysaccharide or poly I/C, monocytic intracellular IL6 production tended to increase in the patient group
Summary
Dedicated to the neurobiology of schizophrenia, this issue opens with an immunohistochemical study on changes in hypothalamic VGF expression by Busse et al [1]. The authors investigated the relation of increased levels of the VGF fragment 23–62 in CSF to changes in hypothalamic VGF expression. They found first evidence for diminished hypothalamic VGF levels in schizophrenia, significant in subjects without metabolic syndrome.
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