Abstract
The article presents the review of 94 publications. It describes experiments on latent tuberculosis infection on Cynomolgus macaques. It has been noted that in recent years, PET-CT has been used to identify thoracic lymph nodes (LN) infected with Mycobacterium tuberculosis (MTB). It has been demonstrated that FDG-PET-CT allows concluding about the presence of viable MTB in thoracic LNs in case of latent tuberculosis infection which is confirmed by detection of live MTB in granulomas of these LNs by culture. The preventive therapy contributes to a significant reduction of pathology visible on PET-CT. The review analyzes publications that experimentally show the spectrum of the immune response to MTB-specific proteins ESAT-6 and CFP10 in case of tuberculosis infection, in particular, the relationship between the cytokine response and bacterial load.
Highlights
The article presents the review of 94 publications
It has been demonstrated that FDG-PET-CT allows concluding about the presence of viable Mycobacterium tuberculosis (MTB) in thoracic lymph nodes (LN) in case of latent tuberculosis infection which is confirmed by detection of live MTB in granulomas of these LNs by culture
The preventive therapy contributes to a significant reduction of pathology visible on PET-CT
Summary
The article presents the review of 94 publications. It describes experiments on latent tuberculosis infection on Cynomolgus macaques. Обнаружили, что 90,65% (194 из 214) ЛУ, видимых при ПЭТ-КТ-сканировании, содержали пригодные для культивирования МБТ, тогда как 83,33% Что ЛУ являются нишей для персистирующей инфекции и, вероятно, играют более важную роль в патогенезе туберкулеза, чем предполагалось ранее.
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