Abstract
Caffeine has been considered a neuroprotective agent against Parkinson’s disease (PD). Recent metabolomic analysis showed that levels of caffeine and its metabolites were decreased in sera from patients with PD compared with those from healthy controls. We focused on theophylline, which is one of the primary caffeine metabolites, as a candidate biomarker of PD because: (1) its serum level can be measured in hospital laboratories by standardized immunoassay kits for therapeutic drug monitoring and (2) because it is less markedly affected by caffeine intake. This was a pilot study to measure the levels of theophylline in sera of 31 patients with PD and 33 age-matched disease controls using an immunoassay kit. We confirmed the previous finding of significantly lower levels of serum theophylline in the PD group compared with control group (PD: 0.07±0.09 μg/mL, control: 0.18±0.24 μg/mL, p<0.05). Using such an approach of applying known medical biomarkers for neurodegenerative diseases may allow us to skip the process from the discovery phase to clinical application, and subsequently shorten the period of time necessary for biomarker development.
Highlights
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease (AD)
We focused on the diagnostic value of serum theophylline for PD, one of the primary caffeine metabolites, for the following reasons
There was no significant difference in age or sex between the PD and control groups
Summary
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease (AD). There is no drug or treatment strategy proven to be neuroprotective or disease-modifying for PD patients. To achieve efficient disease-modification in the early phase of the disease, biomarkers that aid with the presymptomatic diagnosis of PD are critical. Nuclear radiological biomarkers with isotopes including 123I-Ioflupane have been widely. Serum theophylline offers a potential diagnostic biomarker of Parkinson’s disease and Technology of Japan to T.K. and Dainippon Sumitomo Pharma Research grant (2017 to TK and 2018 to TO). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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