Biomarker or Pathophysiology? The Role of DNA Methylation in Postpartum Depression

Abstract

EpigenomicsVol. 5, No. 5 EditorialBiomarker or pathophysiology? The role of DNA methylation in postpartum depressionMary Kimmel, Zachary Kaminsky & Jennifer L PayneMary KimmelJohns Hopkins School of Medicine, Department of Psychiatry, 550 N Broadway, Suite 305, Baltimore, MD 21205, USASearch for more papers by this author, Zachary KaminskyJohns Hopkins School of Medicine, Department of Psychiatry, 550 N Broadway, Suite 305, Baltimore, MD 21205, USASearch for more papers by this author & Jennifer L PayneJohns Hopkins School of Medicine, Department of Psychiatry, 550 N Broadway, Suite 305, Baltimore, MD 21205, USA. Search for more papers by this authorEmail the corresponding author at Jpayne5@jhmi.eduPublished Online:24 Sep 2013https://doi.org/10.2217/epi.13.51AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: biomarkerdepressionDNA methylationestrogenpostpartumReferences1 Campbell SB, Cohn JF. Prevalence and correlates of postpartum depression in first-time mothers. J. Abnorm. Psychol.100(4),594–599 (1992).Crossref, Google Scholar2 O’Hara MW. Postpartum depression: what we know. J. Clin. Psychol.65(12),1258–1269 (2009).Crossref, Medline, Google Scholar3 Dietz PM, Williams SB, Callaghan WM, Bachman DJ, Whitlock EP, Hornbrook MC. Clinically identified maternal depression before, during, and after pregnancies ending in live births. Am. J. Psychiatry164(10),1515–1520 (2007).Crossref, Medline, Google Scholar4 Yonkers KA, Ramin SM, Rush AJ et al. Onset and persistence of postpartum depression in an inner-city maternal health clinic system. Am. J. Psychiatry158(11),1856–1863 (2001).Crossref, Medline, CAS, Google Scholar5 Payne JL, Roy PS, Murphy-Eberenz K et al. Reproductive cycle-associated mood symptoms in women with major depression and bipolar I disorder. J. Affect. Disord.99,221–229 (2007).Crossref, Medline, Google Scholar6 Viguera AC, Tondo L, Koukopoulos AE, Reginaldi D, Lepri B, Baldessarini RJ. Episodes of mood disorders in 2,252 pregnancies and postpartum periods. Am. J. Psychiatry168(11),1179–85 (2011).Crossref, Medline, Google Scholar7 Forty L, Jones L, Macgregor S et al. Familiality of postpartum depression in unipolar disorder: results of a family study. Am. J. Psychiatry163(9),1549–53 (2006).Crossref, Medline, Google Scholar8 Murphy-Eberenz K, Zandi PP, March D et al. Is perinatal depression familial? J. Affect. Disord.90(1),49–55 (2006).Crossref, Medline, Google Scholar9 Payne JL, MacKinnon DF, Mondimore FM et al. Familial aggregation of postpartum mood symptoms in families with bipolar disorder. J. Bipolar Disord.10(1),38–44 (2008).Crossref, Medline, Google Scholar10 Mahon PB, Payne JL, MacKinnon DF et al. Genome-wide linkage and follow-up association study of postpartum mood symptoms. Am. J. Psychiatry166(11),1229–1237 (2009).Crossref, Medline, Google Scholar11 Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. Effects of gonadal steroids in women with a history of postpartum depression. Am. J. Psychiatry157(6),924–930 (2000).Crossref, Medline, CAS, Google Scholar12 Guintivano J, Arad M, Gould TD, Payne JL, Kaminsky ZA. Antenatal prediction of postpartum depression with blood DNA methylation biomarkers. Mol. Psychiatry doi:10.1038/mp.2013.62 (2013) (Epub ahead of print).Medline, Google Scholar13 Nassa G, Tarallo R, Ambrosino C et al. A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics11,159–165 (2011).Crossref, Medline, CAS, Google Scholar14 Cao S, Iyer JK, Lin V. Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein. Biochem. Biophys. Res. Commun.345,310–317 (2006).Crossref, Medline, CAS, Google Scholar15 Schmidt MV, Trümbach D, Weber P et al. Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. J. Neurosci.30(50),16949–16958 (2010).Crossref, Medline, CAS, Google Scholar16 Dennis CL, Dowswell T. Psychosocial and psychological interventions for preventing postpartum depression. Cochrane Database Syst. Rev.2,CD001134 (2013).Medline, Google ScholarFiguresReferencesRelatedDetailsCited ByGenetics of perinatal obsessive–compulsive disorderProtocol for Pilot Study on Self-Management of Depressive Symptoms in Pregnancy2 August 2019 | Nursing Research, Vol. 69, No. 1Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature9 August 2018 | Current Psychiatry Reports, Vol. 20, No. 9DNA methylation: conducting the orchestra from exposure to phenotype?6 September 2016 | Clinical Epigenetics, Vol. 8, No. 1Bidirectional psychoneuroimmune interactions in the early postpartum period influence risk of postpartum depressionBrain, Behavior, and Immunity, Vol. 49 Vol. 5, No. 5 Follow us on social media for the latest updates Metrics Downloaded 188 times History Published online 24 September 2013 Published in print October 2013 Information© Future Medicine LtdKeywordsbiomarkerdepressionDNA methylationestrogenpostpartumFinancial & competing interests disclosureThis work was funded in part by a NARSAD 2010 Young Investigator Award to Z Kaminsky and K23 MH074799-01A2 to JL Payne. Z Kaminsky and JL Payne are coinventors listed on a patent application for DNA methylation at biomarker loci related to postpartum depression. In the past year, JL Payne has conducted consulting work for AstraZeneca and Johnson & Johnson. JL Payne also has a grant from Corcept Pharmaceuticals. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download