BIOMAGNETISM OF DRUG-SENSITIVE AND DRUG-RESISTANT MALIGNANT TUMORS AFTER INJECTION OF FERROMAGNETIC NANOCOMPOSITE.

Abstract

To measure magnetic signals from transplantable rat tumors and their counterparts resistant to cytostatics for evaluating thefeatures of theaccumulation of iron-containing nanocomposite Ferroplat. Doxorubicin (Dox)-sensitive and Dox-resistant Walker-256carcinosarcoma and cisplatin-sensitive and cisplatin-resistant Guerin's carcinoma transplanted in female Wistar rats were studied. Themagnetism of tumors, liver and heart was determined using Superconductive Quantum Interference Device (SQUID)- magnetometry in a non-contact (13mm over thetumor) way using specially designed computer programs. In a group of theexperimental animals, a ferromagnetic nanocomposite (Ferroplat) was administered as a single intravenous injection and biomagnetism was assessed in 1h. Themagnetic signals coming from Dox-resistant Walker-256carcinosarcoma in theexponential growth phase were significantly higher in comparison with sensitive tumor. Intravenous administration of Ferroplat increased biomagnetism by at least an order of magnitude, especially in resistant tumors. At thesame time, themagnetic signals of theliver and heart were within themagnetic noise. Theuse of SQUID-magnetometry with ferromagnetic nanoparticles as a contrast agent is a promising approach for visualization of malignant neoplasms with varying sensitivity to chemotherapy.