Abstract
The dry Urtica cannabina L. extract, containing complex of biologically active materials in different regimes introduced to mice with conducting poly-chemotherapy for the purpose of reduction in its toxicity. As a result a pathomorphological study of the liver of mice it was proven that the extract of U. cannabina decreases the manifestation of the toxic action (dystrophia and the necrosis of the hepatocytes) of poly-chemotherapy on a liver. Most effective is the regime of extract introduction before and after poly-chemotherapy.
Highlights
Ñóõîé ýêñòðàêò Urtica cannabina L., ñîäåðæàùèé êîìïëåêñ áèîëîãè÷åñêè àêòèâíûõ âåùåñòâ, ââîäèëè ìûøàì âíóòðèæåëóäî÷íî ïðè ïðîâåäåíèè ïîëèõèìèîòåðàïèè ñ öåëüþ ñíèæåíèÿ åå òîêñè÷íîñòè
The dry Urtica cannabina L. extract, containing complex of biologically active materials in different regimes introduced to mice with conducting poly-chemotherapy for the purpose of reduction in its toxicity
As a result a pathomorphological study of the liver of mice it was proven that the extract of U. cannabina decreases the manifestation of the toxic action of poly-chemotherapy on a liver
Summary
Èññëåäîâàëàñü íàäçåìíàÿ ÷àñòü ê. êîíîïëåâèäíîé, ñîáðàííàÿ â Íîâîñèáèðñêîé îáëàñòè â ôàçó öâåòåíèÿ â 2008 ã. Êîíîïëåâèäíîé, ñîáðàííàÿ â Íîâîñèáèðñêîé îáëàñòè â ôàçó öâåòåíèÿ â 2008 ã. Îáùèé ôèòîõèìè÷åñêèé àíàëèç ïðîâåäåí ôàðìàêîïåéíûìè è îáùåïðèíÿòûìè ìåòîäèêàìè. Àíàëèç êîìïîíåíòíîãî ñîñòàâà è êîëè÷åñòâåííîãî ñîäåðæàíèÿ áèîëîãè÷åñêè àêòèâíûõ âåùåñòâ (ÁÀÂ) ïðîâîäèëè ìåòîäàìè òèòðèìåòðèè, ãðàâèìåòðèè, õðîìàòîãðàôèè, ñïåêòðîôîòîìåòðèè, õðîìàòîñïåêòðîôîòîìåòðèè, âûñîêîýôôåêòèâíîé æèäêîñòíîé õðîìàòîãðàôèè, ÿäåðíî-ìàãíèòíîãî ðåçîíàíñà, àòîìíî-ýìèññèîííîé ñïåêòðîñêîïèè ñ èíäóêòèâíî ñâÿçàííîé ïëàçìîé [15]. Êîíîïëåâèäíîé ïîëó÷àëè ìåòîäîì äðîáíîé ìàöåðàöèè ïðè íàãðåâàíèè. ×àñòè æèâîòíûì âíóòðèæåëóäî÷íî ÷åðåç çîíä ââîäèëè ÝÊÊ ïîñëå ÏÕÒ (ÏÕÒ + ÝÊÊ), à ÷àñòè — äî è ïîñëå ÏÕÒ (ÝÊÊ + ÏÕÒ + ÝÊÊ) â äîçå 200 ìã/êã ìàññû òåëà â òå÷åíèå 3 è 7 ñóò. Ïðåïàðàò ñðàâíåíèÿ — -òîêîôåðîë àöåòàò ( -Ò) â äîçå 1,7 ìã/êã ìàññû òåëà â êðàõìàëüíîé ñëèçè ââîäèëè æèâîòíûì â àíàëîãè÷íîì ðåæèìå. Çàáîð ìàòåðèàëà äëÿ ïîñëåäóþùåãî ïàòîìîðôîëîãè÷åñêîãî èññëåäîâàíèÿ ïðîèçâîäèëè íà 3-è è 7-å ñóò ïîñëå ÏÕÒ. Äëÿ ãèñòîëîãè÷åñêîãî èññëåäîâàíèÿ ïå÷åíü ôèêñèðîâàëè â 10%-ì íåéòðàëüíîì ôîðìàëèíå, Òàáëèöà 1
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