Abstract
Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.
Highlights
Frontiers in SurgeryAneurysms: A Review of Current Understanding and Future Directions
We focus on saccular aneurysms
Enriched genes encoding TLR, nuclear factor-κB (NF-κB), hypoxia-induced factor 1A, and Ets transcription factor-binding sites were identified. These findings suggest that, both aneurysm groups have an immunologic pedigree, ruptured and unruptured aneurysms likely have different immunologic biology
Summary
Aneurysms: A Review of Current Understanding and Future Directions. Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes
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