Abstract
The article shows that the current level of physiology does not disclose the biological mechanisms of the organism transition from one range to adapt to a higher with an increase in the regular forces of the stimulus above sub-extreme. A new trend in the physiology of adaptation - proqredient adaptation, explains the mechanism of increasing the tolerance of the organism, with dependence on psychoactive substances (PAS ). It is scientifically proved, that dependences of the organism on PAS are the states of progredient adaptation.
Highlights
Review ArticleBiology of increased tolerance and validation of the psychoactive substance dependence
Urgency of the issue: It is known, that at the pick of dependence on any psychoactive substance (PAS), a person, for example, an opium addict uses doses, which are multiple times, almost 10 times, higher than the lethal dose for an ordinary person [3, p.23]
Lack of adaptive reactions of the organism already known in physiology to explain the adaptation mechanisms in response to a further increase in the regular stimulus strength above the sub-extreme level in PAS dependent patients
Summary
Biology of increased tolerance and validation of the psychoactive substance dependence. Corresponding Author: D.G.Baitubayеv, Department of Psychiatric and drug addiction in the Psychiatric Dispensary, Ridder city, Kazakhstan. Received date: November 03, 2021; Accepted date: November 18, 2021; Published date: January 03, 2022
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