Biology of aging in an Israeli population. 2. Polymorphic blood markers and fluctuating asymmetry

Abstract

The major objectives of the present study were to detect whether there are any differences in genetic blood markers distribution between the young and old Israeli population. We also investigated the question about the relationship between the genetic heterozygosity (H) and fluctuating asymmetry (FA) of an individual. The study sample consisted of 208 elderly people aged between 75 and 94 years old. Each individual was assessed for the same 18 anthropological traits, 8 of which were paired bilateral structures and 10 were size and mass measurements. Thirteen polymorphic gene markers were also taken from each individual. Most of the studied gene systems showed no inter-group (old sample vs 207 young individuals) differences. Significant differences were detected at ADA, ESD, GTP1 and FY loci. These differences were mainly due for the considerably lower frequency of the heterozygous individuals in elderly samples. Our working hypothesis at the next stage of the analysis were as follows: 1. Morphologically central phenotypes are more symmetric (processes lower FA) than morphologically extreme individuals. 2. There is a detectable negative correlation between the FA and individuals H. To study these questions we developed a multivariate measure of FA and morphological deviation of the individual from the population centroid. Yet, no reliable evidence in support of either of the two hypotheses were obtained.