Abstract
Drug resistance to common antibiotics has resurfaced, prompting the development of novel therapeutics such as nanoparticles (NPs). In this work, the silver nanoparticles (AgNPs) were synthesized by the cell-free extract produced by the Streptomyces strain and characterized using standard analytical techniques. The size of NPs was found to be in the range of 10-30 nm. The biologically synthesized AgNPs exhibit potent antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. In addition, AgNPs inhibited the growth of clinically isolated pathogenic strains, including Methicillin-resistant Staphylococcus aureus (MRSA) and tetracycline-resistant Neisseria gonorrhoeae. Furthermore, these AgNPs have reduced the development of Pseudomonas aeruginosa biofilm by 80%, one of the key contributors to the increased resistance among bacteria. The inhibition was confirmed using crystal violet assay and confocal microscopic images indicating the future application of AgNPs as a coating material on medical devices used in treating patients to inhibit biofilm formation.
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