Abstract
Neutrophils contain the enzyme myeloperoxidase, which oxidizes Cl − ions into the powerful oxidant hypochlorous acid (HOCl). HOCl inactivates α 1antiprotease, permitting uncontrolled protease activities. Most anti-inflammatory drugs tested are capable of reacting with HOCl, but the reactions seem insufficiently rapid under physiological conditions to protect α 1-antiprotease against inactivation by HOCl. However, rapid scavenging of HOC1 might contribute to the anti-inflammatory effects of penicillamine, gold sodium thiomalate, phenylbutazone and primaquine.
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