Abstract
Components of mycobacterial cell walls were evaluated for antitumor activity. The function of the peptidoglycolipid “cell wall skeleton“ (CWS-I) in the suppression and regression of a strain-2 guinea pig hepatoma was described. P3, a toxic free lipid found in both wax D and cord factor, was also described. For prevention (suppression) of tumor growth, CWS-I was as effective as the untreated BCG cell wall, but P3 was not effective. However, for regression of established tumors with a frequency comparable to that obtained with untreated BCG cell wall, it was necessary to combine the P3 with the CWS-I. When tumor growth was suppressed or regression accomplished, immunity to a subsequent tumor challenge was always demonstrated. The contributions of CWS-I and P3 to tumor suppression and regression were discussed.
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