Abstract
The presence of an alkamide in lichens is reported for the first time. The alkamide was isolated from Stereocaulon alpinum Laur. and identified through spectroscopic analysis as 9-cis-octa-decenamide (1). With reference to previously known activity of alkamides from both the plant and animal kingdoms on inflammatory processes, 1 was tested for in vitro inhibitory activity against the key enzymes of the major pathways involved in arachidonate metabolism. The compound was shown to exhibit moderate dose-dependent inhibitory activity against cyclooxygenase from sheep seminal vesicle microsomes (IC(50) = 64.3 μM) whilst showing only slight activity against 5-lipoxygenase from porcine leucocytes.
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