Abstract
This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the “problems” of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater “stiffness” in the extracellular matrix and either the “soft” cancerous state or the “soft” neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal.
Highlights
Is Biomacromolecular Dysfunction a Cause or Biomarker of Disease?The vast medical research literature contains extensive documentation of dysfunctional changes in biomacromolecular structure and activity seen in chronic and infectious diseases
Could these findings show how an external electromagnetic field modulates interfacial water stress (IWS) leading to the unfolded protein response (UPR), perhaps by increasing the hydrophobicity of water? nitric oxide synthase (NOS) activation requires calcium-binding to calmodulin
Liboff [175], and Del Giudice [161] has employed the principles of quantum electrodynamics (QED) in attempting to explain biological ion cyclotron resonance (ICR), especially the results reported by Zhadin and coworkers, who observed increased ion currents in aqueous glutamic acid solutions exposed simultaneously to weak static and alternating magnetic fields [167,176,177]
Summary
The vast medical research literature contains extensive documentation of dysfunctional changes in biomacromolecular structure and activity seen in chronic and infectious diseases. We begin our “water-based” view of the etiology of disease in Section 2 below, where we briefly discuss key developments in diagnostic and analytical instrumentation that have enabled scientists to measure properties of water essential to life, to obtain evidence for water’s crucial role in determining and maintaining normal macromolecular structure and function, and to detect differences between water structure in normal and diseased tissue. These findings show biological water structure disruptions as causes of pathology.
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