Abstract
Brain natriuretic peptide (BNP) and its N-terminal prohormone (NT-proBNP) fragment have been shown to be effective in diagnosing left ventricular dysfunction (1)(2), and in particular, they have a strong negative predictive value (3). NT-proBNP and the hormone are secreted on an equimolar basis, but NT-proBNP lacks a clearance receptor. It therefore has a longer half-life in serum than the active hormone does, and its circulating concentration is believed to be less influenced by the conditions under which the blood sample is taken. Information on the biological variation of NT-proBNP is not available; this is limiting because the clinical utility of laboratory data can be affected by physiologic variation (4). Here we report the results of …
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