Abstract
Visual cortex is organized into discrete sub-regions or areas that are arranged into a hierarchy and serves different functions in the processing of visual information. In retinotopic maps of mouse cortex, there appear to be substantial mouse-to-mouse differences in visual area location, size and shape. Here we quantify the biological variation in the size, shape and locations of 11 visual areas in the mouse, after separating biological variation and measurement noise. We find that there is biological variation in the locations and sizes of visual areas.
Highlights
Mammalian neocortex is generally considered to be organized into discrete anatomically and functionally defined sub-regions or areas
Visual areas are arranged into a hierarchy and serve different functions in the processing of visual information [3] and yet the sizes and shapes of visual areas appear to vary across individuals of a given species
Retinotopic maps differ across mice (S1 Fig)
Summary
Mammalian neocortex is generally considered to be organized into discrete anatomically and functionally defined sub-regions or areas. How much variation is there in the locations, sizes and shapes of cortical areas from mouse to mouse? We noted that retinotopic maps of cortical visual areas differed between mice [2], but did not quantify these differences or determine the relative contributions of biological variation and measurement noise.
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