Abstract
Poor health due to suboptimal nutrition influences on many diseases including diabetes mellitus, obesity, cardiovascular diseases (CVD), elevated cholesterol and blood pressure (BP). World health organization estimated that mortality rate and disease burden due to CVD was around 17.3 million. The prevalence rate of coronary artery diseases (CAD) is higher in Pakistan that is 30% of people age above 45 years. The objective of study involves evaluation of commonly used fats and oil to investigate its effect on lipid profile through in vivo studies. Hypercholesterolaemia was induced by feeding high cholesterol diet. Thirty Sprague dawdle rats were taken having five rats in each group. Margarine, butter, vanaspati ghee and olive oil were given with a specific dose 10 g/100 g feed given 6 weeks on hypercholesterolaemic rats. Maximum weight gain was observed in G2, G3, G4 fed; margarine, butter, vanaspati ghee respectively. And maximum reduction in weight was observed in G5 fed on olive oil. Feeding cholesterol diet showed elevated level of lipid profile in G1. Coincident giving various fats and oil along with high cholesterol diet caused a highly significant increase in serum total cholesterol, low density lipoprotein (LDL), triglycerides except G5. Maximum increase of cholesterol was observed in groups fed butter, margarine, vanaspati ghee were recorded as 177.6 mg/dL, 185.5 mg/dL, 180.7 mg/dL. Minimum reduction in cholesterol was recorded in olive oil group as 170.2 mg/dL. Results suggested that the addition of fats showed a negative influence on lipid profile in hypercholesterolaemic rats.
Highlights
Atherosclerosis is the most prominent root of cardiovascular diseases (CVD)
Several evidence have recognized that cholesterol rich diet including intermediate density lipoprotein (IDL), very low density lipoproteins (VLDL), apolioprotein B (Apo-B), and their constituent directly related in the formation of atherosclerotic cardiovascular diseases (ASCVD) [2]
When rats were fed with high-cholesterol diet, there was a significant increase in the serum total cholesterol level and LDL cholesterol levels in all groups
Summary
Atherosclerosis is the most prominent root of cardiovascular diseases (CVD). Hypercholesterolaemia is a disease in which level of flowing low density lipoprotein (LDL) in blood is increased. It is known as main modifiable risk factor of CVD. Cardiovascular diseases (CVD) are main public health issue and major cause of mortality and morbidity in western world. The major cause of metabolic syndrome, such as hypertension, obesity and diabetes is due to elevated consumption of fats. Several evidence have recognized that cholesterol rich diet including intermediate density lipoprotein (IDL), very low density lipoproteins (VLDL), apolioprotein B (Apo-B), and their constituent directly related in the formation of atherosclerotic cardiovascular diseases (ASCVD) [2]. Energy provided by 1g fat is 9 Kcal while 4 Kcal provided from carbohydrate and protein
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