Biological Studies and Spectroscopic investigation of 4-Methyl Benzylimine Schiff Base Metal Complexes

Abstract

Primary benzyl amines are highly important building blocks in the pharmaceutical and polymer industry. A new Schiff base ligand named (4-Methyl benzyl 2-Hydroxy 5-NitroAceto) imine was prepared through condensation reaction of 4-Methyl Benzyl amine and 2-hydroxy 5-Nitro Acetophenone in 1:2 molar ratios. The new ligand was characterized by spectral techniques. The coordination behaviour of a series of transition metal ions named Mn(II), Co(II), Zn(II) and Cd(II) with the newly prepared Schiff base ligand is reported. From IR spectra, it was observed that the ligand is a neutral bidentate ligand which coordinates to the metal ions through protonated phenolic oxygen, azomethine nitrogen and nitrogen atom of NH2 group. The molecular structures of the Schiff base ligand and its metal complexes were optimized theoretically. The synthesized ligand and its complexes were screened for antimicrobial activities against bacterial species. It was found that the compounds have shown activity against the organisms like Candida albicans, Bacillus subtilis and Salmonella typhi.