Abstract
The effects of amino acid substitutions in positions 1, 3, or both, and 8 of oxytocin on the contractile response of the estrogenized rat uterus in vitro have been studied inherently and in relation to the magnesium content of the ambient fluid. It was found that: (a) the side-chain of the amino acid residue in position 3 can participate both in processes concerned with intrinsic hormonal activity and in reactions concerned with the affinity of the hormone for its receptor; (b) magnesium cannot only affect the affinity of hormone for receptor, but can also alter intrinsic hormonal activity; (c) the potentiating effect of magnesium tends to increase with decreasing specific biological activity (potency) of the neurohypophyseal peptides (agonists) and this effect can be due not only to a change in agonist-receptor affinity, but to alteration in maximum response (intrinsic activity) as well. (Endocrinology 83: 979, 1968)
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