Abstract
This study compared the levels of HOXA10 in oral samples from normal mucosa and oral squamous cell carcinoma (OSCC) samples and analyzed the effects of overexpression and neutralization of HOXA10 in modulating the main events associated with tumorigenesis. Study Design: The levels of HOXA10 were evaluated by qRT-PCR, and HOXA10 effects on tumorigenic phenotypes were evaluated on HaCaT normal keratinocytes overexpressing HOXA10 and on HSC-3 tongue carcinoma cells expressing a shRNA neutralizing sequence. Results: The expression of HOXA10 was significantly higher on OSCC samples when compared to normal tissues. HaCaT cells overexpressing HOXA10 showed higher expression of N-cadherin and β-catenin, and adhesion and migration were coordinately regulated on those cells. The neutralization of HOXA10 reduced significantly the proliferation but induced the expression of EMT markers and the adhesion, migration, and invasion of HSC-3 cells. Conclusion: Results suggest that HOXA10 expression modulates important events associated with the development and progression of OSCCs.
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