Biological properties and enzymatic degradation studies of clindamycin-loaded PLA/HAp microspheres prepared from crocodile bones

Abstract

Polylactic acid (PLA)/hydroxyapatite (HAp) biocomposite microspheres with a specific core–shell structure for application as drug carriers were synthesised using an ultrasound field. In addition, the loading efficiency of clindamycin phosphate increased when the HAp content was increased to 30%. The effect of HAp content on enzymatic degradation of PLA/HAp microspheres loaded with clindamycin phosphate was that the degradation rate increased with increasing HAp content. Apatite formed on the surfaces of the PLA and PLA/HAp microsphere loading of clindamycin phosphate showed Ca and P peaks in energy-dispersive X-ray spectroscopy (EDX) data. In addition, the PLA and PLA/HAp microspheres loaded with clindamycin phosphate did not show any cytotoxicity against the human lung fibroblast MRC-5.