Abstract
Some of the principles which influence the extent of a programme for particulates within an industrial toxicology laboratory are presented with emphasis on the approaches adopted at ICI's Central Toxicology Laboratory. Here, new techniques have been introduced both for the generation of atmsopheres and monitoring of animals. A new type of inhalation chamber is described for exposing rodents to materials as part of a chronic toxicity/carcinogenicity study programme. This chamber has been designed to reduce manpower and eliminate the need for different types of chambers required for the various physical forms of atmospheres that can be encountered. Some factors which must be taken into account in the extrapolation of animal data to man are discussed. In particular, the value of additional tests for assessing lung function following exposure is presented together with a description of the non-invasive method used.
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