Abstract
Abstract : We have completed a hospital based molecular epidemiologic study of breast cancer that included 119 cases, 109 benign breast disease (BBD) controls and 141 healthy controls. Blood samples were collected prior to surgery from surgical enrollees and from the healthy controls during routine gynecologic exams. Tumor and normal tissue from cases and benign tissue from BBD controls was collected from the pathology blocks. The primary biomarker analyses included aromatic-, heterocyclic amine-, and smoking related-DNA adducts in white blood cells, PAR-DNA adducts and p53 mutations in breast tissue. Another goal of the study was to create a repository of tissue and blood samples linked to pathology and questionnaire data to support future studies. These samples were used for complimentary analyses of xenobiotic metabolizing genes (GSTM1, NAT2 and CYP1A1) and pilot studies of oncoproteins (cyclin D1 and ras p21) and organochlorines (DDE, DDT and PCBs) in blood. The study generated data that support the hypothesis that environmental exposures to PAR and gene-environment interactions play a role in breast cancer etiology.
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