Abstract
Materials/Methods: From 1993 to 2001 a total of 151 patients (89 with hepatocellular carcinoma and 62 with gastric cancer) underwent 3DCRT to part of liver were included in this study. The isocenter dose ranged from 33.0 to 66.0Gy (mean: 48.0Gy). Dose distribution and the corresponding volumetric data were obtained from the computerized planning system. A complication (RILD) was defined as grade 3 or higher RTOG liver toxicity within 4 months after completing 3DCRT. Patient-related and dosimetric factors were tested for their correlation with RILD in univariate and multivariate analyses. A maximal likelihood analysis was used to yield the best estimates for the parallel NTCP model parameters of the whole group and the subgroups. Patients were divided by statistically significant non-dosimetric factors, which were integrated into the modeling process for better describing the occurrence of RILD. Goodness of fit analysis was used to estimate the deviance of NTCP model parameters of subgroups from the whole group.
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