Abstract
In order to evaluate the endocrine-disrupting effects of the styrene oligomers in polystyrene, used in cups for instant noodles, we examined the effects of styrene monomer (SM), styrene dimers (SD: NSD-01, 08, 09) and styrene trimers (ST: NST-01, 02, 03) on the estrogen receptor (ER) binding assay, the androgen receptor (AR) binding assay, the proliferation of MCF-7 human breast cancer cells, the steroidogenesis in Leydig cells of rats and the uterotrophic assay of immature rats. SM, SD and ST did not significantly bind to ER or AR of rats, did not induce the proliferation of MCF-7 cells, did not inhibit testosterone production in Leydig cells of rats, and did not induce estrogen-like alteration in the uterus and vagina of immature female rats. Therefore, it appears that these SM, SD and ST have no endocrine-disrupting effects through ER, AR and steroidogenesis mechanisms.
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