Abstract
Four new Schiff bases with promising anticancer activity have been synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole and di-pyridyl-aldehydes. Structures have been established by various spectroscopic methods. The compounds were tested in vitro to study their cytotoxicity and anti-oxidative activity in human lung carcinoma (A549), breast carcinoma (BT549), prostate adenocarcinoma (PC3) and mouse preadipocytes (3T3-L1) cells. Compound 1 was found to increase Glutathione (GSH) level slightly in all four cell lines. Compound 4 showed better selectivity and cytotoxicity against both BT549 and A549 cells compared to the anticancer drug tamoxifen. With the exception of compound 4 which reduced GSH levels in A549 and BT549, all other compounds maintained GSH levels in comparison to their respective controls.
Highlights
Cancer is the major cause of death in the present world
We report the cell viability and oxidative properties of four Schiff bases on three cancer cells and one obese cell lines
All four different cell lines were cultured under 5% CO2 atmosphere at 37 ̊C in Dulbecco’s Modified Eagle’s Medium (DMEM) supplemented with 10% (v/v) bovine calf serum (BCS) and 1% (v/v) penicillin-streptomycin following literature procedure [23]
Summary
Cancer is the major cause of death in the present world. Approximately 14 million cancer cases was diagnosed and 8.2 million people died because of cancer in 2012 [1] [2]. There are several drugs that contain 1,2,4-triazole nucleus such as Letrozole and Anastrozole (anticancer drug), Alprazolam (anxiolytic drug), Rizatriptan (antimigrane drug), Ribavirin (antiviral drug), Itraconazole and Fluconazole (antifungal drug). Schiff bases and their metal complexes are usually considered one of the most biologically active chemical compounds. Schiff bases synthesized from aldehydes or amines containing heterocyles have been reported to have cytotoxic [7] [8], antiproliferative [9], antibacterial acitivity [8] [9] [10] [11], antiviral [8] [11], antifungal and anticancer activities [11]. Bases on three cancer cells and one obese cell lines
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