Abstract
Abstract This study examined the biocompatibility of the micro-nanoporous layer formed on a titanium-silver (Ti–Ag) alloy. The porous layer was formed by grit-blasting and anodic oxidation. The surface of the porous layer was rougher and more hydrophilic compared to a simple machined specimen and the expressions of bone-related genes were greater for cells grown on the porous layer compared to that of cells cultured on a control surface. Also the bone-to-plate contact rate in vivo test was significantly improved for porous layer plate compare to simple machined specimen (P < 0.05). The porous layer on Ti–Ag alloy enhanced the peri-implant bone formation at the early healing stage and it was believed that this porous layer on the Ti–Ag alloy will be suitable for dental implant applications.
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