Abstract
Intracerebral hemorrhage (ICH) has extremely high morbidity and mortality, substantially impacting public health. Studying the pathophysiological mechanisms of ICH is a complicated undertaking, and there remains a lack of effective medical treatment for improving ICH survival rates and promoting recovery. This review describes the preclinical studies of intracerebral hemorrhage that have been performed to date in detail, including different methods used to establish animal models and identify the cellular mechanisms involved after ICH. Recently, it was reported that the endogenous hydrogen sulfide (H2S) pathway is downregulated in the brain after ICH. Thus, exogenous H2S may have therapeutic potential by rescuing the decreased levels of endogenous H2S level after injury. Furthermore, we also discuss the molecular mechanisms involved in the protective effects of H2S and how these effects may have therapeutic use to treat and prevent ICH-induced neuronal injury.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
