Abstract
Deoxyribonucleic acid (DNA) synthesis is inhibited in gastric mucosa after injection into guinea pigs of rabbit antisera against antigens from guinea pig gastric and colonic mucosa. Rabbit antisera against antigens from guinea pig colonic mucosa also inhibit DNA synthesis in colonic mucosa, while antisera against gastric mucosa do not have any effect on the colon. DNA synthesis in gastric mucosa tends to be decreased in rabbits with circulating autoantibodies against antigens from stomach and colon, but DNA synthesis is significantly increased in colonic mucosa of the same rabbits.
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