Abstract
Mesenchymal stem cells or mesenchymal stromal cells (MSCs) have been considered as a carrier of therapeutic gene because of their inherent ability to migrate to the tumors, and yet there are controversial reports suggesting the tumor-promoting and tumor-inhibiting effects of MSCs. Al-Toub and colleagues provide further insights into the cellular interactions between MSCs and tumors and demonstrate that conditioned media derived from different cancer cells could influence MSC phenotype and gene expression. These changes in MSCs may be modulated by the tumor-derived interleukin-1 beta (IL-1β) and transforming growth factor-beta (TGF-β) signaling.
Highlights
Mesenchymal stem cells or mesenchymal stromal cells (MSCs) have been considered as a carrier of therapeutic gene because of their inherent ability to migrate to the tumors, and yet there are controversial reports suggesting the tumor-promoting and tumor-inhibiting effects of MSCs
Correspondence: cmrlyp@nccs.com.sg 1Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11, Hospital Drive, Singapore 169610, Singapore 2Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 21 Lower Kent Road, Singapore 119077, Singapore Full list of author information is available at the end of the article
Mishra and colleagues [8] have independently shown that MSCs exposed to conditioned media from the same MDA-MB-231 breast tumor cells could differentiate into carcinoma-associated fibroblasts and become part of the tumor microenvironment
Summary
Mesenchymal stem cells or mesenchymal stromal cells (MSCs) have been considered as a carrier of therapeutic gene because of their inherent ability to migrate to the tumors, and yet there are controversial reports suggesting the tumor-promoting and tumor-inhibiting effects of MSCs. Correspondence: cmrlyp@nccs.com.sg 1Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11, Hospital Drive, Singapore 169610, Singapore 2Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 21 Lower Kent Road, Singapore 119077, Singapore Full list of author information is available at the end of the article This attraction is thought to be mediated through a paracrine signaling loop between the chemoattractants from the tumor microenvironment and the expression of the corresponding receptors in MSCs or vice versa.
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