Abstract
The application of fast neutrons in radiotherapy has been stimulated by the expectation that, in comparison with low LET radiations, differences in radiobiological factors might result in a larger relative biological effectiveness (RBE) and lower oxygen enhancement ratio (OER). The biological effects of a mixed neutron-gamma field, due to the nuclear physics reaction, depend on the physical parameters (energy spectra, fluxes, fluences, etc.) of the component of the radiation determined by the facility and the high LET particle used, releasing from the nuclear reaction. Accepting that the biological effects of the low and high LET radiation are different the knowledge of the most important RBE and OER values is critical in application of fast neutron irradiation facility for radiobiological research and therapeutical purpose.
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