Abstract
The phosphorylated histone H2AX protein (γ-H2AX) is expressed after induction of DNA double strand breaks caused by ionizing radiation, created as lymphocytes pass through and adjacent to the irradiated field. We have used γ-H2AX foci formation in peripheral blood lymphocytes as a surrogate marker of radiation dose to the heart and great vessels in patients receiving adjuvant external beam radiation therapy (EBRT) and intraoperative radiation therapy (IORT) for early breast cancer to evaluate the differences between the radiation therapy techniques in terms of dose to the heart, and to assess the utility of this biological technique to provide valid dosimetry data.
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