Biological Determinants of Difficult to Treat Patients with Schizophrenia

Abstract

Numerous studies have attempted to relate brain morphology to treatment outcome in schizophrenia in an attempt to define subtypes of schizophrenia that may respond well to antipsychotic treatment (Brown & Herz, 1989). This has potential clinical significance since, if we can predict outcome based on brain structure, it would then influence treatment.