Abstract
The three most commonly used polymeric materials in orthopedic-surgical applications are polymethylmethacrylate, ultrahigh molecular weight polyethylene, and silicone rubber. These three materials have radically different bulk properties, and somewhat different surface properties. Nevertheless, all three polymers may be found in particulate form is association with inflammation, osteolysis, and joint loosening. The bulk and surface property contributions of these polymers to the elicitation of inflammation are explored using silicone as a model. It suggested that the relatively hydrophobic polymer surfaces adsorb biological macromolecules from surrounding milieu, denature those adsorbed molecules, and initiate an inflammatory reaction that results in inadvertent (innocent bystander) damage to the implant/bone interface.
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