Biological characteristics of human fetal skin fibroblasts and MG-63 human osteosarcoma cells on tantalum-doped carbon films

Abstract

Tantalum is considered a highly biocompatible metal with high corrosion resistance. Metal-doped amorphous carbon films are gaining interest as an effective surface modifier for medical devices. In this study, tantalum (Ta), TaC/amorphous carbon (a-C), and Ta-containing amorphous hydrogenated carbon films (Ta-C:H) were synthesized using a twin-gun magnetron sputtering system to improve biological properties and explore potential applications for surgical implants or devices. Reactive C2H2, activated by the tantalum plasma in the magnetron sputtering process, was used to deposit the Ta-C:H coatings. The deposited TaC/a-C coatings, in which TaC was embedded in the amorphous carbon matrix as a nanocomposite film, exhibited favorable cell viability of the human osteosarcoma cell line (MG-63), similar to uncoated titanium. Among the examined materials, Ta-C:H coatings exhibited the highest biocompatibility for WS1 human fetal skin fibroblast cells derived from soft tissues and demonstrated the highest biological performance.