Abstract
As a new type of intestinal stent, the MAO/PLLA/paclitaxel/Mg–Zn–Y–Nd alloy stent has shown good degradability, although its biocompatibility in vitro and in vivo has not been investigated in detail. In this study, its in vivo biocompatibility was evaluated by animal study. New Zealand white rabbits were implanted with degradable intestinal Mg–Zn–Y–Nd alloy stents that were exposed to different treatments. Stent degradation behavior was observed both macroscopically and using a scanning electron microscope (SEM). Energy dispersion spectrum (EDS) and histological observations were performed to investigate stent biological safety. Macroscopic analysis showed that the MAO/PLLA/paclitaxel/Mg–Zn–Y–Nd stents could not be located 12 days after implantation. SEM observations showed that corrosion degree of the MAO/PLLA/paclitaxel/Mg–Zn–Y–Nd stents implanted in rabbits was significantly lower than that in the PLLA/Mg–Zn–Y–Nd stent group. Both histopathological testing and serological analysis of in vivo biocompatibility demonstrated that the MAO/PLLA/paclitaxel/Mg–Zn–Y–Nd alloy stents could significantly inhibit intestinal tissue proliferation compared to the PLLA/Mg–Zn–Y–Nd alloy stents, thus providing the basis for designing excellent biodegradable drug stents.
Highlights
Bowel obstruction due to intestinal stricture formation is a wellknown complication of enteral diseases, including malignant and benign strictures
Magnesium alloy stents exposed to different treatments were implanted into the intestinal tracts of New Zealand white rabbits and the degradation and supporting properties of the intestinal stents coated with paclitaxel were investigated
The results showed that the micro-arc oxidation (MAO)/PLLA/paclitaxel/Mg–Zn–Y–Nd alloy intestinal stents had better corrosion resistance than the PLLA/Mg–Zn–Y–Nd alloy intestinal stents
Summary
Bowel obstruction due to intestinal stricture formation is a wellknown complication of enteral diseases, including malignant and benign strictures. Scaffold surface polymer coating is important for mechanical strength.[16] Degradable polymers, such as PLLA, PLGA, have good plasticity, mechanical properties, and biocompatibility, which are most commonly used biomaterials for surface modi cation of alloys to enhance the corrosion resistance of alloys.[17,18,19,20,21] PLLA is considered as a coating material to improve the corrosion resistance of magnesium alloy surface in this paper. Various processes such as electrochemical, thermodynamic and plasma chemical reactions occur, accompanied by spark discharge to produce thicker, harder and wear-resistant ceramic coatings that can effectively improve the corrosion resistance of the alloy surface.[22,23] to reduce neointimal growth, biodegradable magnesium alloy stents can be coated with polymers containing antiproliferative drugs. It has been reported in literatures that both
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