Biological and Clinical Relevance of Long Non-Coding RNA PCAT-1 in Cancer, A Systematic Review and Meta-Analysis

Atefeh Talebi,Sara Ashtari,Mohamad Amin Pourhoseingholi,Gholam Reza Mobini,Abolfazl Akbari

doi:10.31557/apjcp.2019.20.3.667

Abstract

Long non-coding RNA (lncRNA) prostate cancer associated transcript 1 (PCAT-1) has been identified as a potential biomarker for the diagnosis and prognosis of various cancers. We performed this systematic review and meta-analysis to evaluate the role of dysregulation as well as the biological and clinical significance of lnc-PCAT-1 for predicting the malignancy status in several cancers. Two independent reviewers conducted an extensive search in electronic databases of Medline, Embase, Scopus, Web of Science and PubMed until the December of 2017. Five articles investigating the clinical significance of lncRNA PCAT-1, including 996 patients, were analyzed. Our results revealed that the increased PCAT-1 expression was related to overall survival (OS) (HR = 1.9, 95% CI: 1.13-3.18, P=0.015). Also, pooled results of the diagnostic data analysis demonstrated that PCAT-1 has a sensitivity of 0.59 and specificity of 0.66 for cancer diagnosis. Moreover, pooled area under curve was 0.62 (95% CI: 0.58–0.69). This meta-analysis revealed that lncRNA PCAT-1 could be served as a potential diagnostic and prognostic biomarker in various solid tumors.

Highlights

Long non-coding RNAs are RNA transcripts characterized by a length about 200 nucleotides or more in length
The characteristics of the study First, 1460 articles were extracted from electronic databases and after removing duplicate articles, 980 articles were screened according to a potential prognostic or diagnostic role of Long non-coding RNA (lncRNA) prostate cancer associated transcript 1 (PCAT-1) in cancers
The ROC curve was symmetrical and the area under curve (AUC) was 0.66, which presents an advanced diagnostic accuracy for diagnosing of various cancers.The results reveal that lncRNA PCAT-1 have an advanced diagnostic value for esophageal squamous cell carcinoma, colorectal, prostate, hepatocellular carcinoma and gastric cancers

Summary

Introduction

Long non-coding RNAs (lncRNAs) are RNA transcripts characterized by a length about 200 nucleotides or more in length. These RNA molecules have been shown to regulate the gene expression at the transcriptional and post-transcriptional levels (Beermann et al, 2016; Parikshak et al, 2016; Adams et al, 2017; Qian et al, 2017). A number of studies have reported the aberrant expression of lncRNAs in various malignancies (Beermann et al, 2016; Parikshak et al, 2016; Adams et al, 2017; Qian et al, 2017). It has been demonstrated that lncRNAs are correlated with clinicopathological features in cancer patients and could be served as potential diagnostic and prognostic biomarkers (Wang et al, 2016; Chandra Gupta and Nandan Tripathi., 2017; Li et al, 2017)

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Results

Conclusion