Abstract
Chronic urticaria is a common and recurrent allergic disease in dermatology. Antihistamines are the first-line treatment of chronic urticaria, but nearly half of patients show poor responses to antihistamines. Complicated pathogenesis of chronic urticaria, including imbalance of Th1/Th2 cell subsets and abnormality of inflammatory mediators, IgE and anti-FceRⅠ antibody, may be one of the important reasons why chronic urticaria is hard to cure. Biological agents can selectively regulate or inhibit immune abnormality, and have become a new approach to the treatment of chronic urticaria and other urticaria-related skin diseases. Related biological agents mainly include BCG-polysaccharide nucleic acid, gamma globulins, tumor necrosis factor (TNF) -α inhibitors, interleukin (IL) -1 blockers, rituximab, omalizumab, and so on, and play important roles in the treatment of chronic urticaria. Omalizumab, a kind of anti-IgE monoclonal antibody, has a favorable benefit/risk ratio and good tolerability, and is considered to be one of the ideal biological agents for the treatment of chronic urticaria. Key words: Urticaria; Biological agents; Antibodies, monoclonal; Rituximab; Omalizumab
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