Abstract
In Wistar male and female rats 18 allometric, physiological and biochemical parameters, which characterize age-related changes of the body weight and weights of some organs, cardiovascular system, oxidation-reduction processes, connective tissue system, loss of active protoplasm mass and altered protein synthesis have been studied. Correlation with age has been revealed for the following indices: relative musculus gastrocnemius weight, heart collagen, body weight, blood circulation index, aorta Cu content, oxidized glutathione of blood, heart weight, cardiac output, relative heart weight, heart rate (males); heart collagen, aorta Cu content, labile skin collagen, aorta Zn content, thermolability of liver glucose-6-phosphate dehydrogenase, aorta collagen, body weight, heart weight, musculus gastrocnemius weight, relative musculus gastrocnemius weight (females). Cardiovascular indices (besides HR) are recognized to be unsuitable for a test battery because they are determined at acute experimental conditions under anesthesia and may interfere with some other indices. With a value of the age-correlation coefficient and consistency of the parameters with such criteria as unidirectness of the age-dependent changes in view, the following indices have been suggested for estimation of the biological age of Wistar rats. For males these indices are: relative muscular gastrocnemius weight, heart weight, heart rate and aorta copper content. Heart collagen may probably be added to the list as it correlates highly with age though for males this index increases gradually only up to the pre-senile age, decreasing thereafter. For females these indices are gastrocnemius weight, heart collagen, labile skin collagen, thermolability of liver glucose-6-phosphate dehydrogenase and body weight. Because of its relatively close correlation with age and simplicity of determination aorta copper should probably be included into the list, although this parameter is not strictly unidirectional.
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