Abstract
The chromophore free apoprotein of neocarzinostatin was coupled to monoclonal IgG 1 antibody using N-Succinimidyl 3-(2-pyridyldithio)-propionate as heterobifunctional reagent. After coupling active chromophore was reassociated with the apoprotein. We present here experimental evidence that the hybrid protein retains biological activity as measured by the degradation of T2-DNA and bacteriostatic action.
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More From: Biochemical and Biophysical Research Communications
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