Abstract
Four steroids were tested for their biological activity, using the sex-steroid-dependent redevelopment of the secondary sex characteristics in adult frogs and gonadal sex differentiation in larval frogs as end points. In adult frogs, 19-norprogesterone and 6-chloro-17α-hydroxy-4, 6-pregnadiene-3, 20-dione had antiandrogenic and antiestrogenic effects. 2α, 17α-Dimethyl-DHT and 2α-methyl-DHT were potent androgens and effective antiestrogens. In the larval frogs, all four compounds had a masculinizing effect upon the undifferentiated gonads.
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