Abstract
The roles of phenolics from olive oils as effective anticancer agents have been documented in various in vitro studies of different cancer cells lines, but the relationship between the phenolic profile of olive oil and its biological activity needs more elucidation. In this study, we analysed phenolic profiles of extra virgin olive oils (EVOOs) from different autochthonous cultivars from Croatia (Oblica, Bjelica, Buža, Žižolera) and investigated the biological effect of EVOO phenolic extracts (EVOO-PEs) on human cervical (HeLa) and human colon (SW48) cancer cell lines alone and in combination with cisplatin (cDDP), carboplatin (CBP), 5-fluorouracil (5-FU) and irinotecan. The quantitative evaluation of olive oil polyphenols was performed by HPLC-DAD and spectrophotometric analysis. The biological effect of EVOO-PEs alone and in combination with anticancer drugs was measured by MTT assay. Analysed EVOO-PEs differ in phenolic profile and inhibited HeLa and SW48 cells in a dose-dependent manner. Further, it is shown that EVOO-PEs (Oblica-Sea, Buža and Žižolera), in combination with anticancer drugs, increase the metabolic activity of HeLa and SW48 cells and have a protective role. These data imply careful consummation of olive oil during chemotherapy of cancer patients.
Highlights
Cancer is one of the leading causes of deaths in the world
We selected samples of five different extra virgin olive oils (EVOOs) from cultivars: Oblica, Buža, Bjelica and Žižolera since we have expected they differ in phenolic profile
Phenolic compounds from EVOOs were extracted using an optimised ultrasound probe assisted liquid-liquid extraction (US-LLE) method [21] and analysed using different methods
Summary
Cancer is one of the leading causes of deaths in the world. In 2018 there were 9.6 million cases of deaths caused by cancer. As the number of cancer cases and deaths is constantly rising, cancer therapy presents one of the major medical challenges with the continuous need for improvement in the therapeutic approach. The most effective approach in the treatment of cancer is surgery combined with chemo and radiotherapy. Due to development of intrinsic or acquired drug resistance as well as side effects of cancer treatment, there is a growing need for more efficient anticancer agents and new strategies that could improve the success of cancer treatment. One of the possibilities is combinations of existing anticancer drugs with polyphenols
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