Biological activity of peptides purified from fish skin hydrolysates

Racheal Abuine,Hee-Guk Byun,Anuruddhika Udayangani Rathnayake

doi:10.1186/s41240-019-0125-4

Racheal Abuine, Hee-Guk Byun + Show 1 more

Open Access

https://doi.org/10.1186/s41240-019-0125-4

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Abstract

Fish skin waste accounts for part of the solid waste generated from seafood processing. Utilization of fish skin by bioconversion into high-grade products would potentially reduce pollution and economic cost associated with treating fish processing waste. Fish skin is an abundant supply of gelatin and collagen which can be hydrolyzed to produce bioactive peptides of 2–20 amino acid sequences. Bioactivity of peptides purified from fish skin includes a range of activities such as antihypertensive, anti-oxidative, antimicrobial, neuroprotection, antihyperglycemic, and anti-aging. Fish skin acts as a physical barrier and chemical barrier through antimicrobial peptide innate immune action and other functional peptides. Small peptides have been demonstrated to possess biological activities which are based on their amino acid composition and sequence. Fish skin-derived peptides contain a high content of hydrophobic amino acids which contribute to the antioxidant and angiotensin-converting enzyme inhibitory activity. The peptide-specific composition and sequence discussed in this review can be potentially utilized in the development of pharmaceutical and nutraceutical products.

Highlights

The marine environment is a source of functional biomaterials such as polyunsaturated fatty acids (PUFAs), polysaccharides, minerals and vitamins, antioxidants, enzymes, and bioactive peptides (Kim and Wijesekara 2010; Kim et al 2008; Pomponi 1999)
The analysis showed that the amino and carboxylate terminal groups, peptide bonds from peptide backbone, amino, and imine from arginine side chain were involved in the formation of a complex with iron
As elaborately discussed in this review, biologically active peptides have been effectively produced through the bioconversion of fish skin

Summary

Introduction

The marine environment is a source of functional biomaterials such as polyunsaturated fatty acids (PUFAs), polysaccharides, minerals and vitamins, antioxidants, enzymes, and bioactive peptides (Kim and Wijesekara 2010; Kim et al 2008; Pomponi 1999). Preparation of bioactive peptides from fish skin Fish protein hydrolysates contain peptides of 2–20 amino acid sequences after hydrolysis, and these peptides usually have biological activity. Higher values of ACE inhibitory activity of hydrolysate in comparison to those of the gelatin are an indicator that bioactive peptides are released from the protein molecules upon enzymatic hydrolysis (Abdelhedi et al 2017).

Results

Conclusion