Abstract
Azo dye of quinoline named 5-(3-pyridylazo)-8-hydroxyquinoline dye (PAHQ) was prepared via coupling reaction of diazonium salt of 3-aminopyridine and 8-hydroxyquinoline. he PAHQ dye was characterized by elemental analysis, mass spectroscopy and 1H-NMR. The complexes of PAHQ dye were prepared under 2:1 (L:M) mole ratio. The complexes were characterized by elemental analysis, infrared spectroscopy, UV-Vis, molar conductance, magnetic susceptibility. The IR spectra data indicate that PAHQ ligand is bidentate through deprotonated phenolic oxygen and nitrogen atom of azomethine of quinoline. The IR spectra also indicate to presence of water in coordination state to metals. The PAHQ and its complexes were found to have high biological activity against different organisms of bacteria and fungi. The PAHQ ligand and zinc complex exhibited high toxicity against MCF-7 with high different values between IC50 against infection cells and healthy cells.
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