Biological activity and disposition of the amphetamine analogue 2-aminopropylferrocene.

Abstract

1. 2-Aminopropylferrocene (FIPA) was rapidly absorbed following intraperitoneal administration to mice. From 5 to 120 min after administration, liver FIPA concn. remained constant while blood concn. declined steadily (t0·5 = 114 min). In contrast, brain concn. of FIPA did not reach max until 30 min after administration, and then declined slowly (t0·5 = 194 min). The apparent vol. of distribution of FIPA was 5·5 1/kg, and high affinity of FIPA for tissue was suggested by brain and liver concn. tenfold greater than blood concn.2. Mice treated with FIPA (3-30 mg/kg) showed no differences in loco-motor activity from saline injected controls. However, at 100 mg/kg FIPA elicited convulsive behaviour in most mice.3. In contrast to amphetamine, which markedly increased the spontaneous beating rate of isolated pargyline-treated rat atria, FIPA exhibited only a dose-dependent depressant effect on atrial rate.4. Rats excreted 56-71% dose of 3H-FIPA in their urine in the first 96 h after dosing. Fractionation of urin...