Abstract
Sinularin ((9E)-13-hydroxy-4,9,13-trimethyl-17-methylidene-5,15-dioxatricyclo[12.3.1.0(4,6)] octadec-9-en-16-one) is the soft coral-derived hopeful biologically active lead compound. In this review sinularin biological activities are summarized. For that, an up-to-date (from 1980 to Mar 2020) search was made in the PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society, Clinicaltrials.gov, and Google Scholar databases. Data available suggest that sinularin has interesting anti-inflammatory, anticancer, anti-fouling and analgesic potential. The inducible nitric oxide synthase (iNOS), cyclooxigenase (COX)-2, tumor growth factor beta 1 (TGF-β1) are the most efficient enzymes for interacting with sinularin due to its anti-inflammatory activity, while phosphoinositol 3-kinase (PI3K), Akt and mechanistic target of rapamycin (mTOR) for its anticancer effect. In conclusion, sinularin seems to be a promissory lead compound in the treatment of inflammation, cancer and neurological disorders.
Highlights
The oceans are home to around 90% of the world’s living biomass, the marine environment is an extraordinary and rich reservoir of bioactive natural products with multiple pharmacological potentialities [1]
Sinularin is a natural compound isolated from marine soft corals (e.g., Sinularia triangular, S. querciformis, S. flexibilis), and increasing evidences have suggest that it possess some important biological effects, including anti-inflammatory and analgesic, anti-fouling and anticancer effects [2,3,8,9]
The present review aims to sketch the current scenario on sinularin biological effects based on scientific reports from various databases
Summary
The oceans are home to around 90% of the world’s living biomass, the marine environment is an extraordinary and rich reservoir of bioactive natural products with multiple pharmacological potentialities [1]. Sinularin is a natural compound isolated from marine soft corals (e.g., Sinularia triangular, S. querciformis, S. flexibilis), and increasing evidences have suggest that it possess some important biological effects, including anti-inflammatory and analgesic, anti-fouling and anticancer effects [2,3,8,9]. It has been isolated and identified 30 years ago, scientific reports regarding its biological effects are not enough. The present review aims to sketch the current scenario on sinularin biological effects based on scientific reports from various databases
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