Abstract
The present study aimed to determine the bioactivities of essential oils extracted from the leaves of Paramignya trimera and Limnocitrus littoralis, including cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas effects. Herein, it was indicated that P. trimera and L. littoralis oils showed no cytotoxicity on normal cells, namely MT-4, BHK-21, MDBK, and Vero-76. P. trimera oil (i) exhibited the strongest inhibition against Staphylococcus aureus with MIC and MLC values of 2% (v/v); (ii) showed MIC and MLC values of 8% (v/v) in Candida parapsilosis; and (iii) in the remaining strains, showed MIC and MLC values greater than or equal to 16% (v/v). On the other hand, L. littoralis oil (i) displayed the strongest inhibition against Candida tropicalis and Candida parapsilosis with 2% (v/v) of MIC and MLC; and (ii) in the remaining strains, possessed MIC and MLC greater than or equal to 16% (v/v). In addition, antitrichomonas activities of the oils were undertaken, showing IC50, IC90, MLC values, respectively, at 0.016%, 0.03%, and 0.06% (v/v) from P. trimera, and 0.03%, 0.06%, 0.12% (v/v) from L. littoralis, after 48 h of incubation. The oils were completely ineffective against ssRNA+ (HIV-1, YFV, BVDV, Sb-1, CV-B4), ssRNA- (RSV, VSV), dsRNA (Reo-1), and dsDNA (HSV-1, VV) viruses. This is the first report describing the cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas activities of the essential oils of P. trimera and L. littoralis.
Highlights
Essential oils, known as volatile oils or ethereal oils, are aromatic oily liquids extracted from different parts of the plants [1] and contain a wide range of chemical compounds, mainly terpenes and terpenoids [2]
In order to give additional information about biological activities of essential oils from P. trimera and L. littoralis collected in Vietnam, we report for the first time the biological activities of the essential oils from the leaves of P. trimera and L. littoralis
The biological activities of P. trimera and L. littoralis essential oils were determined for the first time
Summary
Known as volatile oils or ethereal oils, are aromatic oily liquids extracted from different parts of the plants [1] and contain a wide range of chemical compounds, mainly terpenes and terpenoids [2]. The number of identified essential oils has reached 3000, and most have been used in many applications, namely pharmaceuticals, fragrances, and the food industry [3]. Some of these have been used to treat certain organ and systemic disorders [4]. The extraction of the Paramignya species comprised a wide range of chemical constituents such as coumarins, triterpenes, alkaloids, and glycoside derivatives. The Paramignya species were employed in traditional medication treating cancer, hepatitis, diabetes and nose infections. Their extracted-active compounds exhibited anti-tumour, antioxidant, and anti-inflammatory effects [10]. Our previous research indicated that β-caryophyllene (10.5%), β-caryophyllene oxide (9.9%), 7-epi-α-eudesmol (7.6%), and γ-muurolene (6.8%) were major constituents of the P. trimera essential oil [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
